Full-length RNA sequencing service

Untargeted long-read RNA-seq for bulk tissue and single cells, analyzed and back in under a week.

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Transcript isoformsShort-read sequencingLong-read sequencing
/ isoforms

It’s hard to drug what you can’t see

Nearly every human gene produces multiple transcript isoforms, often with completely different functions. Short reads only capture ~150 bp fragments, making it difficult to reconstruct splicing patterns. That restricts you to the gene level and keeps the set of therapeutic targets smaller than it has to be.

Single-cell PCA scatter plot
/ applications

Built for target discovery, useful well beyond it

For samples you can’t afford to read halfway. Most assays read one end of each transcript; we read every molecule end to end.

  • Synthetic constructs often splice in ways you didn’t design. See what your cells are actually making.

  • See which isoforms a tumor expresses and call its variants in the same run.

  • Read full-length receptors and the whole transcriptome from the same cells.

  • Confirm a cell line’s identity and state before you build on it.

/ what you get

Samples in, everything back in days

Cell Viz showing inferred cell types on a PCA plot and gene expression distributions
Exploration software is included, and every data type can be exported: reads, alignments, expression matrices and more.

Input

  • Bulk tissue or single-cell suspension
  • Cryopreserved, viability post-thaw >70%
  • No sample minimums

Outputs

  • Gene expression and isoforms
  • Whole-exome variant calls
  • V(D)J clonotypes (single-cell)
  • Cell type classification (single-cell)

Depth

  • More long reads per cell than any other long-read solution

Turnaround

  • Under one week

Optional

  • V(D)J enrichment for TCR/BCR clonotypes
  • Cell selection
  • Custom tissue dissociation protocol development
/ compare

More answers from one run and one vendor, not several

Getting gene expression, isoforms, receptors and variants today means combining short-read runs with a separate long-read run, then joining the data yourself.

The usual waySPLICE
Runs for the full picture2–31
Isoforms and splicingA separate long-read runSame run
TurnaroundMonthsDays
Sample minimumsYesNone
BioinformaticsYou provideIncluded
Delivered asA bundle of filesQueryable database
/ Get started

Tell us about your samples

Not sure which assay you need? Describe the experiment and we’ll work it out with you.

Request a quote

  1. Get in touch

    Request a quote or call us, and describe your samples and what you want to learn.

  2. We scope it with you

    You get an assay recommendation, a quote, and a drop-off plan.

  3. Send your samples

    Our automated lab runs them, and the data lands in your workspace.